List<string[]> list = File.ReadLines("YourFile.txt")
.Select(r => r.TrimEnd('#'))
.Select(line => line.Split(','))
.ToList();
string[] lines = theText.Split(
new string[] { "\r\n", "\r", "\n" },
StringSplitOptions.None
);
string[] lines = theText.Split(
new string[] { Environment.NewLine },
StringSplitOptions.None
);